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KMID : 0604520060320020111
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 2 p.111 ~ p.116
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Effects of Esthetic Essential Oils on LPS-Induced Nitric Oxide Generation in Murine Marcrophage RAW 264,7 Cells
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Hong Jin-Tae
Lee Hwa-Jung
Lee Choong-Woo
Choi Myung-Sook
Son Dong-Joo
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Abstract
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Essential oils have been used extensively in pharmacy, medicine, food, beverages, cosmetics, perfumery and aromatherapy. Although anti-bacteria, anti-virus, alleviation of fever operations and an anti-inflammatory properties have been reported, action mechanisms have not been fully discovered. In the present study, anti-inflammatory activities of thirty three essential oils have been evaluated in lipopolysaccharide (LPS)-treated macrophage RAW 264.7 cells by the evaluation of nitric oxide (NO) generation since NO generation is implicated in causal factor of inflammation. Among the tested 33 essential oil, Lemongrass oil showed the most inhibitory effect on LPS-induced NO generation in a dose dependent manner (IC_{50} : 22 {mu}g/mL). In further study, it was found that Lemongrass oil inhibited the expression of inducible nitric oxide synthase. These results suggest that Lemongrass oil may be useful for improvements of the inflammatory disease such as pimple acne skin.
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KEYWORD
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esesential oil, Lemongrass, nitric oxide, RAW 264.7, iNOS, LPS
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